What is Chromatin Immunoprecipitation Sequencing (ChIP-Seq)

Chromatin immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a particular protein of interest. This technique gives a picture of the protein-DNA interactions that occur inside the nucleus of living cells or tissues. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states.

 Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and for disease research.

ChIP-Seq technology can simplify your process for identifying and characterizing protein–DNA interactions.

ChIP (the capture specific DNA-bound proteins) followed by next-generation DNA sequencing allows you to map where proteins bind across the genome.

ChIP-Seq combines the quantification advantage afforded by high numbers of reads with the single-base resolution of sequencing.

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